Dublin: England gave debuts to James Taylor, Ben Stokes and Scott Borthwick as the one-day side were put into bat by Ireland at Clontarf on Thursday.
England, who were led by Dublin-born Eoin Morgan for the first time, omitted Graham Onions and Jonathan Bairstow from a relatively inexperienced 13-man squad.
Morgan, who qualified for England on residency grounds, is the first Irishman to skipper England in over a hundred years since County Kildare-born Frederick Fane took over the captaincy during the Ashes tour of Australia in 1907-08.
Jonathan Trott made made to the England side after missing the last two Tests against India with a shoulder injury.
Ireland captain William Porterfield won the toss - delayed by 15 minutes due to rain - and decided to bowl first despite the absence of opening bowler Trent Johnston with a knee injury.
England will be looking for revenge after Ireland dramatically beat them by three wickets, with Kevin O'Brien scoring the fastest-ever World Cup hundred, when the teams last met in Bangalore in March.