Nottingham: Bangladesh's latest defeat was compounded by Mushfiqur Rahim and Raqibul Hasan both suffering series-ending injuries in the first one-day international against England on Thursday.
Wicketkeeper Mushfiqur, not wearing a helmet, was struck in the face midway at Trent Bridge by a ball from spinner Faisal Hossain and carried off on a stretcher in a match England won by six wickets.
Bangladesh captain Mashrafe Mortaza said Mushfiqur would be out for a week and that means the keeper wil miss both Saturday's second ODI in Bristol and Monday's series finale at Edgbaston.
Earlier Raqibul, who top-scored for Bangladesh with 76 in a six-wicket loss, broke a toe after being struck on the foot by England seamer James Anderson.
Raqibul, who ended up batting with a runner, is out for two weeks, after making his return to international duty in this match having retired in protest at being omitted from the Tigers' World Twenty20 squad.
With the series finishing on Monday, time is short if Bangladesh want to bring in replacements.
"Mushfiqur is still in hospital and he is out for a week," Mortaza said. "Raqibul is out for two weeks, he has a fracture in his toe."
Bangladesh don't have a reserve wicketkeeper in their squad and Mortaza added: "We are trying to bring a keep over maybe, and Mohammad Ashraful or Naeem Islam may be coming over too. But we don't know, we haven't taken that decision."