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Perth: England, in pursuit of 391, were reduced to 81/5 at stumps on Day 3 with Johnson and Harris picking up two wickets each.
A hard-hitting century from Mike Hussey was the highlight of a dominant day by Australia in the third Test at the WACA which saw the Aussies go to stumps needing just five more wickets to level the Ashes at one Test apiece.
Hussey top-scored with 116 while Shane Watson added a heartbreaking 95 - his fourth score in the 90s - as Australia posted 309 in their second innings to set England a massive target of 391 to win and thereby retain the Ashes by taking an unassailable 2-0 lead in the series.
But any hope of England doing this in Perth is all but gone after the tourists slumped to 5-81 by stumps, still needing a further 310 runs to win with two days left to play.
Alastair Cook (13), Andrew Strauss (15), Kevin Pietersen (3), Jonathan Trott (31) and Paul Collingwood (11) all lost their wickets in the final session on Saturday as Australia produced another brilliant session with the ball, having previously bowled England out for 187 in their first innings.
Fresh from taking six wickets on Friday, Mitchell Johnson backed this up by claiming Strauss and Trott to have 2-28, while Ryan Harris has 2-22 as he sent Cook and Collingwood back to the sheds.
England had appeared to have some hope, despite slumping to 3-55, when Ben Hilfenhaus tempted Pietersen to slash outside off-stump, the potential matchwinner caught at first slip by Shane Watson.
Trott and Collingwood had steadied the ship, posting 26 runs, but England's hopes were shattered in the second-last over of the day as Johnson earned an edge from Trott that flew straight to Ricky Ponting in the slips.
The ball actually struck Ponting's hand and appeared to have injured the skipper but it still bounced up for Brad Haddin to take the catch, while Ryan Harris struck with the last ball of the day as he tempted an edge from Collingwood that was well taken by Steve Smith at third slip.
Nightwatchman James Anderson and Ian Bell are the unbeaten batsmen but England will need a miracle to take anything from this Test.
The late wickets almost overshadowed Hussey's effort with the bat.
The veteran Western Australian produced some breathtakingly powerful shots at times on his way to 116, his second Test century in front of an adoring home crowd in Perth, as he treated England's bowlers and specifically Graeme Swann, with contempt at times.
Hussey, though, was the last Australian dismissed in their innings, holing out to the impressive Chris Tremlett searching for quick late runs as the Australian innings collapsed midway through the second session.
In a strong position at 4-252, Steven Smith's dismissal saw Australia lose their last six wickets for just 57 runs, ensuring England's target was more manageable than it really should have been.
Hussey, almost dropped before the series even began after a quiet series in India and some poor Sheffield Shield scores, marked his return to form with another emphatic performance on Saturday as he notched up his second century of the summer.
Having scored 193 in Brisbane, Hussey's effort means he has scored 517 runs at 103.4 over just three Tests for his highest series score, his efforts eclipsing the 458 runs he posted at 91.60 against England during the 2006-07 series.
Hussey was Tremlett's fifth wicket for the innings for 87 runs and his eighth in total in this match, as the beanpole bowler more than justified his inclusion in the side for the injured Stuart Broad.
Tremlett also claimed the vital wickets of Shane Watson (95), Steve Smith (36) and the in-form Brad Haddin (seven) on Saturday, along with Michael Clarke (20) the previous evening.
Watson had looked in imperious form during his stay at the crease, but a lapse in concentration midway through the first session saw him wrapped on the pads by Tremlett five runs short of just his third Test century.
The score means Watson has been dismissed in the 90s four times with a terrible conversion rate, where he has only turned two of 14 half-centuries into tons.
Brief scores
Australia 268 and 309 (Hussey 116, Watson 95, Tremlett 5-87)
England 187 and 81 for 5
Status England need 310 runs to win
