Australia 5 for 355 (Head 152, Warner 106, Stone 4-85) beat England 142 (Roy 33, Zampa 4-31) by 221 runs (DLS method)
Melbourne: Travis Head and David Warner both hit centuries as Australia consigned England to their heaviest one-day international defeat in terms of runs at Melbourne Cricket Ground.
The openers combined for the highest-ever ODI stand at the MCG (269) to help the hosts to 355-5, their largest ODI total against England, in an innings shortened to 48 overs due to rain.
Head blitzed a brilliant 152 from 130 balls and Warner made 106 from 102 deliveries as England were punished for a lacklustre bowling effort in their final game before returning home.
Set a Duckworth-Lewis-Stern (DLS) adjusted 364 to win, England never threatened to get close and were bowled out for 142 with Australia securing a 3-0 series sweep in comprehensive manner.
Adam Zampa took 4-31 as England were dismissed in 31.4 overs.
For both sides, attention now switches to red-ball cricket with Australia hosting West Indies in a two-Test series starting next Wednesday while England begin their three-match tour of Pakistan a day later.