Netherlands 166 for 6 (Myburgh 74, Singh 3-29) beat Ireland 163 (Tector 58, Klaassen 3-23, van Beek 3-29) by four wickets
Utrecht: Ireland went down to a 2-1 series defeat against the Netherlands after losing Monday's final game by four wickets in Utrecht on Monday.
The tourists slipped to 28-3 before Harry Tector (58) and George Dockrell (40) put on an 89-run partnership.
But the last seven wickets fell for just 46 as the Irish were dismissed for a disappointing 163.
Netherlands openers Stephan Myburgh and Max O'Dowd (36) set the foundation for a comfortable win as they made 166-6.
It leaves the Irish with just two wins from their opening nine World Cup Super League matches, with hopes fading of making the 2023 tournament in India.
The hosts won the opener before Ireland levelled thanks to half-centuries from captain Andrew Balbirnie and opener Paul Stirling.
Ireland are reliant on the pair firing and the team once again struggled after their early exits with Stirling out for five while Balbirnie added just 13 runs.
Tector and Dockrell gave the Irish hope but Simi Singh's unbeaten 21 was the only score in double figure after they were dismissed.
Fredrick Klaassen (3-23) and Logan van Beek (3-29) helped the Dutch helped limit the Irish to a modest total and set the Dutch on course for victory.
Myburgh hit three maximums and six boundaries with his opening stand of 66 with O'Dowd laying the foundation for an untroubled run chase.
The win was brought up with over four overs to spar while Singh was the best of the Irish bowlers as the spinner took 3-29.