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Brisbane: Pakistan were 2 for 70 in their mammoth chase of 490 after Australia declared on 5 for 202 in Brisbane on Saturday.
Azhar Ali not out on 41 and Younis Khan not out without open account. Mitchell Starc picked up opener Sami Aslam on 15. Second wicket of Babar Azam took by Nathan Lyon.
Earlier, captain Steve Smith and Usman Khawaja scored half-centuries to drive Australia to a mammoth lead of 489 with five wickets in hand at dinner.
Usman Khawaja scored 74 and captain Steve Smith smashed 63 off 70 balls as the home side sought to bat Pakistan out of the game after declining to enforce the follow-on on a steamy day at the Gabba.
Australia were five for 202 in their second innings, with Peter Handscomb unbeaten on 35 and wicketkeeper Matthew Wade on one.
Smith declined to declare the innings closed before the break but is likely to put Pakistan in to bat quickly in the evening session with the pink ball at its most devilish.
Pakistan were bowled out for 142 before tea, 287 runs short of Australia's first innings 429 and 88 shy of making their opponents bat again.
The tourists were buoyed by two early wickets late in the second session but Smith and Khawaja wrested back the momentum on a sun-baked pitch that offered little succour for the bowlers.
Smith, who top-scored with 130 in the first innings, was eventually dismissed by leg-spinner Yasir Shah after slogging to Rahat Ali at long-on.
Khawaja was out for 74 with Pakistan captain Misbah-ul-Haq taking a fine catch off the bowling of Rahat.
Opener David Warner was earlier out for a free-swinging 12, skying a pull shot off Mohammad Amir for an easy catch at mid-on for Wahab Riaz.
Rahat grabbed his first wicket of the match when he had opener Matt Renshaw edge to Younus Khan for six in the slips.
Routed by Australia's seamers late on day two, Pakistan resumed in the afternoon on 97-8, and wicketkeeper Sarfraz Ahmed and Mohammad Amir built a plucky 54-run partnership before paceman Jackson Bird struck to remove Amir for 21.
Rahat was run out for four with a piece of typical fielding brilliance from Warner to wrap up the innings, leaving Sarfraz stranded on 59.
Brief scores
Australia - 429 (Smith 130, Handscomb 105, Renshaw 71, Wahab 4-89, Amir 4-97) and 5 for 202 dec (Khawaja 74, Smith 63)
Pakistan - 142 (Sarfraz 59*, Hazlewood 3-22, Bird 3-23, Starc 3-63) and 2 for 70 (Azhar Ali 41*)
Status - Pakistan require 420 runs to win
