Dublin: Ireland lost to Pakistan by 255 runs in the first of two one-day internationals between the sides at Malahide on Thursday.
This was the seventh largest victory, in terms of runs, in the 3,767-match history of ODIs.
Pakistan piled up 337-6 in a match reduced by rain to 47 overs per side, with Sharjeel Khan scoring 152.
Ireland were bowled out for just 82 inside 24 overs in reply, with left-arm spinner Imad Wasim taking 5-14.
Sharjeel's 152 was the third quickest 150 in the format in terms of balls faced, his innings coming off 86 balls and including 16 fours and nine sixes.
He racked up his maiden ODI century in just 61 balls, registering Pakistan's fourth fastest ton in the format.
Shoaib Malik's unbeaten 57 and 53 from Mohammad Nawaz provided effective support in a game delayed by early poor weather.
Already faced with a massive target, Ireland's reply could hardly have got off to a worse start when Mohammad Amir clean-bowled Paul Stirling with the innings' second ball.
Captain William Porterfield could only muster 13 before the fit-again Umar Gul upended his stumps, and the wickets continued to fall at regular intervals.
Gul (3-23) sent back Ed Joyce for nine before then snaring Kevin O'Brien, reducing Ireland to 32-4.
Slow left-armer Imad then took centre-stage, first claiming the scalp of Niall O'Brien for 10, stumped by Sarfraz, and then dismissing Stuart Poynter lbw for four.
Gary Wilson's short burst came to an end on 21, Nawaz drawing another stumping from Sarfraz.
Imad then finished things in emphatic fashion with three wickets in four balls, bowling each of McCarthy, Murtagh and Chase to leave Andy McBrine unbeaten on 14.
The teams will meet again at the same venue on Saturday.
After the two encounters with Pakistan, Ireland will finish their season with further one-day internationals against South Africa on 25 September and Australia on 27 September - both in Benoni, South Africa.
Pakistan are using the games as preparation for five one-day internationals against England, having drawn the recent Test series between the countries.
Brief scores
Pakistan - 337 for 6 (Sharjeel 152, Malik 57*, Nawaz 53, McCarthy 4-62)
Ireland - 82 (Wasim 5-14, Gul 3-23)
Result - Pakistan won by 255 runs